Endocrine Abstracts

Introduction: Hirsutism is described as excessive development of facial and body hair in women in androgen-dependent areas. Our aim was to determine the clinical and metabolic aspects of hirsutism and its relationship with the metabolic syndrome.Methods: We conducted a retrospective descriptive study at the endocrinology department of Rabta Hospital in Tunis. We recruited 100 women who presented with hirsutism between January 2009 and December 2020 Clini...

Introduction: Hirsutism is defined as excessive hair growth in androgen-dependent areas in women, related to an increased exposure androgen action in pilosebaceous follicles. It may be isolated, or associated to cutaneous manifestations from acne to signs of virilism. The aim of our study was to describe the therapeutic and evolutionary aspects of hirsutism.Methods: It was a retrospective study at the endocrinology department of Rabta Hospital in Tunis i...

Introduction: There is an association between Moyamoya syndrome and Graves’ disease, described primarily in Asian populations. We report a case of Moyamoya vasculopthy with stroke and hypertension associated with graves’ disease in a 15-year-old Tunisian girl.Observation: A 15-year-old girl diagnosed with Moyamoya vasculopathy was referred to the endocrinology department for hyperthyroidism. The patient had a history of recurrent stroke and hyp...

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...

Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including ...

Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin t...

Introduction: Patients with type 2 diabetes mellitus are considered at least at high cardio-vascular risk. Cardiovascular risk factors must be regularly screened. Hyperhomocysteinemia is considered as an independent risk factor for atherosclerotic disease and coronary disease in some studies. The aim of our study was to confirm the association between hyperhomocysteinemia and atherosclerotic disease in patients with type 2 diabetes.Methods: We performed ...

Introduction: Endocrine complications are common in beta thalassemia major (BTM) patients receiving blood transfusions. Chelation therapy has a role in preventing such complications. However, patients may have difficulties adhering to chelation therapy. We aimed in this study to determine the endocrine complications in BTM patients.Methods: This was a descriptive study with cross-sectional data collection over a 6 month period from February 2022 to July ...

Liver dysfunction is common in patients with hyperthyroidism. The underlying mechanisms remain unclear. Predictors of liver dysfunction and recovery are controversial. The aim of this study was to assess the prevalence of elevated liver enzymes in patients with uncontrolled hyperthyroidism and to identify its predictive factors.Methods: This is a retrospective study conducted in 131 patients with hyperthyroidism admitted in the endocrinology department o...

Introduction: Although the association between parathyroid and thyroid diseases is not uncommon, the coexisting of parathyroid adenoma causing primary hyperparathyroidism (PHPT) and papillary thyroid carcinoma (PTC) is rare. Probably this can be partially explained by different embryologic origin of thyroid and parathyroid cells. Herein, we report a case of PHPT associated with synchronous bifocal PTC.Observation: A 65-year-old woman was referred to our ...